Synthesis, Characterization and Biological activity Study of Some New Metal Complexes With Schiff’s Bases Derived from [Ο-Vanillin] With [2-Amino-5-(2-Hydroxy-Phenyl)- 1,3,4-Thiadiazole]

Shaalan, Naser Dheyaa; Abdulwahhab, Shatha

doi:10.21608/ejchem.2021.66235.3432

Synthesis, Characterization and Biological activity Study of Some New Metal Complexes With Schiff’s Bases Derived from [Ο-Vanillin] With [2-Amino-5-(2-Hydroxy-Phenyl)- 1,3,4-Thiadiazole]

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq

² Ministry of Education , Al-Karkh Second Education Directorate, Baghdad, Iraq

10.21608/ejchem.2021.66235.3432

Abstract

Abstract
This study involves the preparation of a new series of dinuclear complexes Cr(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base (H2L) derived from Vanillin with 2amino-5-(2-hydroxy-phenyl)-1,3,4-thiadiazole has been synthesized tetradentate Schiff base ligands were used for complexation upon two metal ions of Cr(III),Co(II), Ni(II), Cu(II) and Zn(II) as dineucler formula M2L2.4H2O and M2L2. These ligands can be characterization IR ,UV-Vis , Mass, 1H-NMR and elemental microanalysis. The Synthesized complexes were characterized by IR, spectroscopy, elemental microanalysis, electronic spectra, magnetic susceptibility conductive ,thermal Analysis (TGA) and atomic absorption on the basis of analytical data, the stoichiometry of metal to ligand in complexes and Schiff bases ligand. The Structures of complexes were proposed from the measurements. The bioactivity of the prepared complexes has been examined with antibacterial activity. Antimicrobial activities of the Schiff base ligand and their metal complexes reveal that the Schiff base transition metal complexes show significant activity against some fungi and bacteria.

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