The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients

Document Type : Original Article

Authors

1 Department of chemistry, Collage of Education for Girls, University of Mosul, Mosul, Iraq

2 Department of chemistry, Collage of Science, University of Mosul, Mosul, Iraq

Abstract

This research included study the relation between FGF21 and insulin resistance in hyperlipidaemia. The results demonstrated that the normal mean of FGF21 in serum control group was (69.4±2.9 pg/ml) and there was a significant increasing in FGF21 concentration in patients (108.05±4.03 pg/ml ) compared with control group, also the results showed a significant increase in the concentration of fasting glucose, insulin, homeostasis model for insulin resistance (HOMA-IR), Total cholesterol, Triglycerides, low density lipoprotein for cholesterol (LDL-C) and very low density lipoprotein for cholesterol (VLDL-C) and Malondialdehyde (MDA), while a significantly decrease had been shown in concentration of high density lipoprotein for cholesterol (HDL-C), adiponectin and Arylestase activity in hyperlipidemia patients compared with control group. Correlation coefficients of FGF21 hormone with these clinical parameters showed a positivly significant correlation with Glucose, insulin, HOMA-IR, Total cholesterol, Triglycerides, LDL-C, VLDL-C and MDA concentration, while FGF21 elucidated a significant negative correlation with HDL-C, arylesterase activity and adiponectin concentration. The conclusion of this study was that FGF21 concentration corelated significantly in hyperlipidemia with insulin resistance, and FGF21 high concentration can be represented as a biomarker in hyperlipidemia.

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History

  • Receive Date: 10 June 2021
  • Revise Date: 17 June 2021
  • Accept Date: 23 June 2021

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